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Related Experiment Video

Updated: Jun 29, 2026

Glycopeptide Capture for Cell Surface Proteomics

Glycopeptide Capture for Cell Surface Proteomics

Published on: May 9, 2014

Cell surface Glycans: from recognition technologies and functional editing to medical applications.

Tingting Zhang¹, Yongbin Xu¹, Yupeng Liu¹

¹The State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, The MOE Key Laboratory for Standardization of Chinese Medicines, SATCM Key Laboratory for New Resources, Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, PR China.

|June 27, 2026

Summary

Cell-surface glycans are crucial for cell communication and disease. Advances in glycan recognition and editing technologies are enabling new medical applications, including diagnostics and therapies.

Keywords:

cell surface glycans glycan editing glycan recognition medical applications

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Last Updated: Jun 29, 2026

Glycopeptide Capture for Cell Surface Proteomics

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Published on: May 9, 2014

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Glycan Node Analysis: A Bottom-up Approach to Glycomics

Published on: May 22, 2016

Profiling Anti-Neu5Gc IgG in Human Sera with a Sialoglycan Microarray Assay

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Area of Science:

Biochemistry and Molecular Biology
Immunology
Medical Technology

Background:

Cell-surface glycans are critical for cellular processes like communication and immune response.
Dysregulated glycans are implicated in various disease states, highlighting their diagnostic and therapeutic potential.
Glycan recognition and editing are key technological pillars for medical glycomics.

Purpose of the Study:

To review advancements in cell-surface glycan recognition and editing technologies.
To explore the synergistic applications of these technologies in medicine.
To provide an integrated perspective on translating glycan research into clinical practice.

Main Methods:

Focus on in situ imaging and glycomic profiling for glycan detection and analysis.
Discuss genetic, enzymatic, chemical, and metabolic approaches for glycan functional editing.
Examine medical applications driven by the synergy of glycan recognition and editing.

Main Results:

Recognition technologies enable precise detection and profiling of cell-surface glycans.
Editing technologies allow for targeted remodeling of glycan structures.
Synergy between recognition and editing drives progress in biomarkers, therapies, and cancer immunotherapy.

Conclusions:

Integrated glycan recognition and editing technologies are essential for clinical translation.
These technologies offer promising avenues for developing novel biomarkers and therapeutics.
The field is advancing the application of cell-surface glycan research in clinical settings.