Related Experiment Video
Updated: Jun 29, 2026
10:11
Glycopeptide Capture for Cell Surface Proteomics
Published on: May 9, 2014
Cell surface Glycans: from recognition technologies and functional editing to medical applications
Tingting Zhang1, Yongbin Xu1, Yupeng Liu1
1The State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, The MOE Key Laboratory for Standardization of Chinese Medicines, SATCM Key Laboratory for New Resources, Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, PR China.
Glycobiology
|June 27, 2026
Summary
Cell-surface glycans are crucial for cell communication and disease. Advances in glycan recognition and editing technologies are enabling new medical applications, including diagnostics and therapies.
Area of Science:
- Biochemistry and Molecular Biology
- Immunology
- Medical Technology
Background:
- Cell-surface glycans are critical for cellular processes like communication and immune response.
- Dysregulated glycans are implicated in various disease states, highlighting their diagnostic and therapeutic potential.
- Glycan recognition and editing are key technological pillars for medical glycomics.
Purpose of the Study:
- To review advancements in cell-surface glycan recognition and editing technologies.
- To explore the synergistic applications of these technologies in medicine.
- To provide an integrated perspective on translating glycan research into clinical practice.
Main Methods:
- Focus on in situ imaging and glycomic profiling for glycan detection and analysis.
- Discuss genetic, enzymatic, chemical, and metabolic approaches for glycan functional editing.
- Examine medical applications driven by the synergy of glycan recognition and editing.
Main Results:
- Recognition technologies enable precise detection and profiling of cell-surface glycans.
- Editing technologies allow for targeted remodeling of glycan structures.
- Synergy between recognition and editing drives progress in biomarkers, therapies, and cancer immunotherapy.
Conclusions:
- Integrated glycan recognition and editing technologies are essential for clinical translation.
- These technologies offer promising avenues for developing novel biomarkers and therapeutics.
- The field is advancing the application of cell-surface glycan research in clinical settings.
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