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Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
Published on: August 8, 2022
Synthesising lithium-alumina-borate glass-ceramic for potential applications in regenerative bone establishment.
Danial Ridzuan1, Nor Ezzaty Ahmad1, Siti Noor Fazliah Mohd Noor2
1Department of Physics, Faculty of Science, Universiti Teknologi Malaysia, Skudai, Johor, 81300, Malaysia.
Biochemical and Biophysical Research Communications
|June 27, 2026
Summary
Lithium-alumina-borate glass-ceramics show promise for bone regeneration. The LA4B composition demonstrated excellent hydroxyapatite formation and biocompatibility with human osteoblast cells.
Area of Science:
- Materials Science
- Biomaterials Engineering
- Biotechnology
Background:
- Lithium-alumina-borate (LAB) glass-ceramics possess promising physicochemical and cytocompatibility properties for bone regeneration.
- Further investigation is required to establish their efficacy in bone tissue repair.
Purpose of the Study:
- To synthesize and characterize lithium-alumina-borate glass-ceramics with varying alumina content (x mol.%) for potential bone regeneration applications.
- To evaluate the in vitro bioactivity, ionic release, and cytocompatibility of these glass-ceramics with SaOS-2 human osteoblast cells.
Main Methods:
- Melt-derived LAB glass-ceramics were synthesized using the formula 70 B2O3-(30-x) Li2O-x Al2O3.
- Characterization involved thermal analysis, X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy with energy-dispersive X-ray (SEM-EDX), pH profile analysis, and in vitro bioactivity testing using simulated body fluid (SBF).
- Cytocompatibility was assessed using MTT assays on SaOS-2 human cell lines.
Main Results:
- Thermal analysis confirmed the stability and glass-forming ability of the LAB glass-ceramics.
- XRD and FTIR analyses indicated hydroxyapatite (HA) formation in LA4B and LA6B compositions.
- SEM-EDX and pH profiles revealed superior HA formation and deposition of calcium and phosphorus on the LA4B surface, suggesting enhanced bioactivity.
- In vitro ionic release studies supported the bioactive and biocompatible nature of the LAB glass-ceramics.
- MTT assays demonstrated good cytocompatibility of LA4B with SaOS-2 cells.
Conclusions:
- LAB glass-ceramics exhibit favorable properties for bone regeneration, with the LA4B composition showing the most promising results.
- The LA4B composition demonstrates significant potential for HA formation and biocompatibility with osteoblast cells.
- Further biological evaluation, including osteogenic differentiation and in vivo studies, is warranted to establish the suitability of LA4B for bone regeneration applications.
