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Published on: October 27, 2023

Pulpal Pressure Aggravates Pulpitis by Mechano-Inflammatory Signal Synergy

Weiqi Hu1, Hao Cui2, Yajing Fu3

  • 1Department of Endodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Oral Biology, School of Stomatology, The Fourth Military Medical University, Xi'an, China.

International Dental Journal
|June 27, 2026
PubMed
Summary

Elevated pulpal pressure exacerbates pulpitis by synergizing with inflammatory signals. This mechano-inflammatory pathway in macrophages leads to increased inflammation and disease severity, suggesting new therapeutic targets.

Keywords:
BiomechanicsEndodonticsInflammationMechanotransductionPulpitis

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