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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Hindlimb Ischemia
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Post-stroke endothelial cell plasticity: A transformational lineage from complete to partial EndoMT.

Siyi Tang1, Cheng Li2, Zhijun Yu3

  • 1School of Pharmacy, Southwest Medical University, 643000, China; Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological, Key Laboratory of Sichuan Province, (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research, Southwest Medical University, Luzhou 643000, China.

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Summary

Endothelial-mesenchymal transition (EndoMT) intermediate states offer a novel target for ischemic stroke treatment. Reversible EndoMT in brain damage presents a critical therapeutic window for intervention.

Keywords:
Cell plasticityEndothelial-mesenchymal transitionIschemic strokeNuclear transitional factorTGF-β

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Pathology

Background:

  • Internationalization of vascular endothelial cells contributes to ischemic stroke progression.
  • Endothelial-mesenchymal transition (EndoMT) is implicated in stroke pathophysiology.
  • The blood-brain barrier's integrity is influenced by EndoMT.

Purpose of the Study:

  • To review the intermediate states of EndoMT in ischemic stroke.
  • To detail key signaling pathways regulating EndoMT.
  • To explore the role of EndoMT in blood-brain barrier function during stroke.

Main Methods:

  • Literature review focusing on EndoMT and ischemic stroke.
  • Analysis of single-cell sequencing data for cellular heterogeneity.
  • Examination of pathophysiological processes including TGF-β signaling, transcription factors, and energy metabolism.

Main Results:

  • EndoMT exhibits intermediate states, some of which are reversible (MEndT).
  • Single-cell sequencing reveals cellular heterogeneity and multiple intermediate phenotypes in EndoMT.
  • TGF-β signaling, transcription factors, and energy metabolism are key contributors to EndoMT.

Conclusions:

  • Intermediate EndoMT states represent a critical target for preventing ischemic stroke progression.
  • Understanding EndoMT heterogeneity provides a basis for novel therapeutic strategies.
  • Targeting EndoMT may be crucial for maintaining blood-brain barrier function in stroke.