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Related Experiment Video

Updated: Jun 29, 2026

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea

Published on: February 21, 2016

Slc16a5 (MCT6) knockout induces sex-dependent changes in auditory function, hair cell viability and cochlear

Arthur Germakovski¹, Mengxiao Ye², Guang-Di Chen³

¹Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Division of Molecular Biosciences, University at Buffalo, State University of New York, Buffalo, NY, USA.

Hearing Research

|June 27, 2026

Summary

This summary is machine-generated.

Monocarboxylate transporter 6 (Mct6) deficiency impacts hearing differently in male and female mice. Mct6 is crucial for cochlear stress resistance and auditory resilience, with sex-specific effects on hearing loss and hair cell survival.

Keywords:

Cochlea Monocarboxylate transporter Sensorineural hearing loss Sexual dimorphism Slc16a5 Transcriptome

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Last Updated: Jun 29, 2026

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Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

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Published on: May 10, 2019

Area of Science:

Inner ear physiology
Auditory neuroscience
Metabolic regulation

Background:

Cochlear homeostasis relies on metabolic regulation.
The role of monocarboxylate transporters, like Mct6, in hearing is unclear.
Mct6 (Slc16a5) transports metabolites vital for cellular energy and signaling.

Purpose of the Study:

Investigate Mct6's role in cochlear physiology, hair cell viability, and molecular stability.
Determine the sex-specific effects of Mct6 deficiency on auditory function.
Elucidate the molecular mechanisms underlying Mct6's influence on cochlear stress resistance.

Main Methods:

Generated Mct6-knockout (Mct6-KO) mice.
Conducted physiological assessments of auditory function.
Evaluated outer hair cell survival.
Performed RNA-sequencing for transcriptomic profiling.

Main Results:

Mct6 deficiency causes sex-dependent cochlear stress resistance.
Female Mct6-KO mice showed early high-frequency hearing loss.
Male Mct6-KO mice exhibited a transient protective phenotype.
Outer hair cell loss was greater in females and reduced in males.
Mct6 deletion altered estrogen-responsive genes and heat shock protein expression differently between sexes.

Conclusions:

Mct6 is a critical, sex-dependent regulator of cochlear homeostasis.
Mct6 influences auditory resilience through sex-specific molecular pathways.
Understanding Mct6's role is vital for addressing hearing loss and inner ear degeneration.