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  1. Home
  2. Complex Patent Foramen Ovale: Anatomic Variants, Technical Considerations, And Outcomes.
  1. Home
  2. Complex Patent Foramen Ovale: Anatomic Variants, Technical Considerations, And Outcomes.

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Related Experiment Video

Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence
10:52

Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence

Published on: December 23, 2022

Complex Patent Foramen Ovale: Anatomic Variants, Technical Considerations, and Outcomes.

Sant Kumar1, Ahmad Jabri2, Arturo Giacaman Saavedra3

  • 1Department of Cardiology, Creighton University School of Medicine, Phoenix, AZ.

Journal of Cardiothoracic and Vascular Anesthesia
|June 27, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Patent foramen ovale (PFO) closure effectively reduces stroke risk in complex cases. Advanced imaging and techniques improve device deployment and patient outcomes for challenging PFO anatomies.

Keywords:
atrial septal aneurysmcomplex patent foramen ovaleintracardiac echocardiography (ICE)multifenestrated septumtranscatheter PFO closure

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Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence
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Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Medical Devices

Background:

  • Patent foramen ovale (PFO) closure is a standard procedure for cryptogenic stroke prevention.
  • Complex PFO anatomies present significant challenges to device deployment and successful closure.
  • Existing literature lacks comprehensive reviews on managing these complex anatomical variants.

Purpose of the Study:

  • To review current evidence and procedural strategies for patent foramen ovale closure in complex anatomies.
  • To highlight advancements in imaging and interventional techniques for challenging PFO cases.
  • To discuss device selection and optimization for improved patient safety and efficacy.

Main Methods:

  • Review of contemporary evidence on PFO closure techniques for complex anatomies.
  • Analysis of imaging modalities (TEE, ICE, 3D imaging) for characterizing complex PFO variants.
  • Evaluation of interventional approaches including tunnel angioplasty and transseptal puncture.

Main Results:

  • Advanced imaging significantly improves detection and characterization of complex PFO features.
  • Tailored procedural approaches and device selection lead to acceptable success rates.
  • Favorable long-term clinical outcomes are achievable even in complex PFO cases.

Conclusions:

  • Complex PFO anatomies require specialized techniques and imaging for successful closure.
  • Current advancements enable safe and effective PFO closure with favorable outcomes.
  • Continued innovation is crucial for further optimizing complex PFO closure procedures.