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Related Concept Videos

Factors Influencing Drug Absorption: Disease States and Pharmacology01:25

Factors Influencing Drug Absorption: Disease States and Pharmacology

Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
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Hypertension (High blood pressure)
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Updated: Jun 29, 2026

Doppler Ultrasound-Based Leg Blood Flow Assessment During Single-Leg Knee-Extensor Exercise in an Uncontrolled Setting
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Alterations in Abdominal Blood Flows After Drinking Coffee.

Soshi Owada1, Shohei Shibasaki2, Yoriko Sei2

  • 1Major in Health Sciences, Kyorin University Graduate School of Health Sciences, Tokyo, Japan.

Pharmacology Research & Perspectives
|June 28, 2026
PubMed
Summary

Drinking coffee reduces blood flow in the superior mesenteric artery (SMA) and portal vein (PV) in adults. This effect, linked to caffeine, may contribute to coffee's health benefits, like preventing fatty liver disease.

Keywords:
blood flowcoffeeportal veinsonographysuperior mesenteric artery

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Published on: July 21, 2023

Area of Science:

  • Gastroenterology
  • Cardiovascular Physiology
  • Nutritional Science

Background:

  • Coffee consumption is linked to various health benefits, including reduced risk of type 2 diabetes, cardiovascular disease, and fatty liver.
  • Caffeine, a component of coffee, is known to affect blood flow, for instance, by decreasing cerebral artery blood flow and treating apnea in premature infants.
  • A potential side effect of caffeine is reduced blood flow in the superior mesenteric artery (SMA), but its impact on abdominal blood flow in adults remains unclear.

Purpose of the Study:

  • To investigate the effects of coffee consumption on hemodynamics in the superior mesenteric artery (SMA) and portal vein (PV) in healthy young adults.
  • To determine if coffee intake alters abdominal blood flow and if this relates to potential health benefits, such as the suppression of fatty liver disease.

Main Methods:

  • A study involving 32 healthy young men (mean age 21 years) was conducted under fasting conditions.
  • Participants consumed either coffee or water, and hemodynamic parameters in the SMA and PV were measured using sonography at 30 and 90 minutes post-consumption.
  • Blood flow volume and pulsatility index in the SMA and PV were analyzed.

Main Results:

  • Drinking coffee led to a significant decrease in SMA blood flow volume (median -13.4%) and an increase in pulsatility index (median 9.0%) 30 minutes after consumption.
  • A concurrent decrease in portal vein (PV) blood flow volume (median -11.3%) was observed after drinking coffee.
  • These hemodynamic changes persisted for 90 minutes and were more pronounced in individuals who habitually consumed low amounts of caffeine. Water consumption did not produce similar effects.

Conclusions:

  • Coffee consumption significantly decreases superior mesenteric artery (SMA) and portal vein (PV) blood flow in healthy young adults.
  • The observed reduction in abdominal blood flow following coffee intake may be a contributing factor to the beneficial effects of coffee on liver health, particularly in the context of fatty liver disease.
  • The findings highlight the physiological impact of coffee on gastrointestinal hemodynamics, with implications for understanding its broader health effects.