Dynamic Changes in Inflammatory Cytokines and T-Lymphocyte Subsets after Endoscopic Submucosal Dissection for Early...

Area of Science:

• Gastroenterology
• Oncology
• Immunology

Background:

• Early gastrointestinal cancers require effective treatment.
• Endoscopic submucosal dissection (ESD) is a minimally invasive endoscopic procedure for resecting early gastrointestinal neoplasms.
• Understanding the impact of ESD on immune status is crucial for patient recovery.

Purpose of the Study:

• To characterize dynamic changes in inflammation and T-lymphocyte subsets after ESD in early gastrointestinal cancer.
• To correlate these changes with resection quality and clinical factors.
• To compare outcomes across different tumor sites and resection groups.

Main Methods:

• 189 patients with early esophageal, gastric, or colorectal cancer undergoing ESD were analyzed.
• Patients were grouped by resection quality: non-R0 en bloc, non-curative R0, and curative R0.
• T-lymphocyte subsets, inflammatory markers, and complications were assessed pre- and post-ESD.

Main Results:

• ESD significantly improved T-lymphocyte subsets and inflammatory cytokines, especially in the curative resection group.
• Marker levels correlated with lesion size, tumor morphology, and invasion depth.
• Curative resection had the lowest complication rate; non-R0 resection had the highest.

Conclusions:

• ESD effectively ameliorates immune dysregulation in early gastrointestinal cancer.
• Resection quality is a key factor influencing therapeutic benefit and complications.
• Immune improvements post-ESD were consistent across different GI cancer sites.