Related Experiment Video
Updated: Jun 30, 2026
Conducting Respiratory Oscillometry in an Outpatient Setting
Published on: April 8, 2022
Development and external validation of a respiratory oscillation score to predict airflow limitation:
Sumito Inoue1, Yoko Shibata2, Hiroshi Nakano1
1Department of Cardiology, Pulmonology and Nephrology, Yamagata University Faculty of Medicine, 2-2-2, Iida-Nishi, Yamagata, Japan.
Background:
Chronic obstructive pulmonary disease (COPD) is frequently underdiagnosed worldwide. Spirometry, the standard method for diagnosing, is often not performed during annual health checkups. MostGraph is a noninvasive, effort-independent device based on respiratory impedance and may serve as an alternative in such settings.
Methods:
This study aimed to develop a scoring system for predicting airflow limitation (AFL, FEV1/FVC <0.7) using the MostGraph device and smoking history. Data from the Yamagata-Takahata study were used as a training cohort, with separate validation cohorts for males and females. MostGraph measurements were combined with the smoking history to predict AFL presence. Logistic regression identified key predictors for males and females, respectively. A scoring system based on these predictors was developed, with higher scores corresponding to higher AFL risk.
Results:
In the training cohort, the model demonstrated good predictive accuracy, with AUROC values of 0.717 for males and 0.684 for females. External validation showed AUROC values of 0.780 for males and 0.631 for females. Calibration curve and decision curve analyses confirmed the clinical utility of the model.
Conclusion:
The present study developed a sex-specific scoring system based on MostGraph measurements and smoking history, which demonstrated good predictive ability for AFL. This scoring system can help prioritize individuals for spirometry, enabling earlier COPD detection and intervention. The findings of this study highlight sex-specific differences in AFL predictors, and underscore the utility of this scoring system in health checkup settings with limited access to spirometry.
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