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Related Concept Videos

Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

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Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

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Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

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Updated: Jun 30, 2026

Targeted Muscle Reinnervation: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain
03:26

Targeted Muscle Reinnervation: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain

Published on: March 8, 2024

Mixed Compartment Syndromes and Neuropathy Resolution With Hyperbaric Oxygen.

Michael Strauss1, Arielle Sass2, Katherine Wilson3

  • 1MemorialCare Long Beach Medical Center, Long Beach, California.

Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc
|June 28, 2026
PubMed
Summary
This summary is machine-generated.

Skeletal muscle compartment syndrome (SMCS) and exertional compartment syndrome (ECS) can occur simultaneously. A single hyperbaric oxygen (HBO₂) treatment resolved residual neuropathy from SMCS in this case report.

Keywords:
exertional compartment syndromehyperoxygenationlag phaseperoneal nerve palsyskeletal muscle-compartment syndrome

Related Experiment Videos

Last Updated: Jun 30, 2026

Targeted Muscle Reinnervation: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain
03:26

Targeted Muscle Reinnervation: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain

Published on: March 8, 2024

Area of Science:

  • Sports Medicine
  • Neurology
  • Orthopedics

Background:

  • Skeletal muscle compartment syndrome (SMCS) and exertional compartment syndrome (ECS) are distinct conditions.
  • This case report details a unique instance where both SMCS and ECS arose from identical triggering events.
  • Residual neuropathy following SMCS is a known complication.

Purpose of the Study:

  • To report a case of concurrent SMCS and ECS.
  • To investigate the resolution of residual neuropathy with hyperbaric oxygen (HBO₂) therapy.
  • To highlight the potential role of HBO₂ in managing SMCS-related nerve deficits.

Main Methods:

  • Retrospective analysis of a patient presenting with severe leg pain after strenuous activity.
  • Documentation of symptoms consistent with both SMCS and ECS.
  • Administration of a single HBO₂ treatment for residual peroneal nerve dysfunction.
  • Subsequent evaluation for ECS and bilateral leg fasciotomies.

Main Results:

  • The patient experienced severe leg pain after intense ballet and gymnastics sessions, indicative of both SMCS and ECS.
  • A steppage gait developed the following day, signifying peroneal nerve palsy.
  • A single HBO₂ treatment successfully restored peroneal nerve function.
  • The patient underwent fasciotomies for ECS and returned to athletic activities symptom-free.

Conclusions:

  • Concurrent SMCS and ECS can result from the same precipitating activity.
  • Hyperbaric oxygen therapy demonstrated efficacy in resolving peroneal nerve palsy secondary to SMCS.
  • This case supports the use of HBO₂ as a therapeutic option for SMCS-induced neuropathy.