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Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

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Updated: Jun 30, 2026

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

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Published on: March 26, 2020

Side Effects of Hyperbaric Oxygen Therapy.

Marvin Heyboer, William Santiago

Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc

|June 28, 2026

Summary

Hyperbaric oxygen (HBO₂) therapy, using 100% oxygen at increased pressure, can cause side effects like barotrauma and oxygen toxicity. Understanding these risks is crucial for patient discussions regarding HBO₂ treatment benefits and drawbacks.

Area of Science:

Medical Treatments
Hyperbaric Medicine
Patient Safety

Background:

Hyperbaric oxygen (HBO₂) therapy involves administering 100% oxygen at elevated atmospheric pressures.
Treatments occur in monoplace or multiplace chambers, with oxygen delivered via mask or hood.
Varying provider expertise necessitates clear understanding of potential HBO₂ side effects.

Purpose of the Study:

To describe and quantify the potential side effects of hyperbaric oxygen therapy.
To inform risk-benefit discussions between patients and healthcare providers considering HBO₂.
To enhance patient safety and informed consent in hyperbaric medicine.

Main Methods:

Review and synthesis of existing literature on hyperbaric oxygen therapy side effects.

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Published on: March 26, 2020

Description of the physiological mechanisms underlying HBO₂ benefits and side effects.

Quantification of reported side effects where data is available.

Main Results:

HBO₂ therapy carries known potential side effects, including barotrauma and oxygen toxicity.
Both primary effects (increased pressure, hyperoxia) and secondary effects (oxidative stress) contribute to benefits and side effects.
Side effects arise from the same physiological mechanisms that provide therapeutic benefits.

Conclusions:

Awareness of HBO₂ side effects is essential for clinical practice.
Informed patient consent requires a thorough discussion of potential risks and benefits.
Further research may be needed to fully quantify and mitigate HBO₂-related side effects.