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Related Experiment Video

Updated: Jun 30, 2026

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
16:56

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

A Guide to Sublingual Immunotherapy in Japan.

Minoru Gotoh1

  • 1Department of Otorhinolaryngology, Nippon Medical School.

Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi
|June 28, 2026
PubMed
Summary

Sublingual immunotherapy (SLIT) tablets effectively treat Japanese cedar pollinosis and house dust mite allergies in Japan, offering sustained remission with a high safety profile. This non-invasive approach shows significant benefits within the first season.

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Area of Science:

  • Allergy and Immunology
  • Pharmacology
  • Otolaryngology

Background:

  • Allergen immunotherapy (AIT) offers sustained remission for Type I allergies.
  • Sublingual immunotherapy (SLIT) is the sole AIT option in Japan for Japanese cedar pollinosis (JCP) and house dust mite (HDM) allergies.
  • SLIT is recognized for its efficacy and safety in managing allergic rhinitis.

Purpose of the Study:

  • To evaluate the efficacy and safety of SLIT tablets for JCP and HDM allergies in Japan.
  • To assess the potential for concomitant administration of JCP and HDM SLIT tablets.
  • To examine the cross-efficacy of JCP SLIT against Japanese cypress pollinosis.

Main Methods:

  • Clinical studies involving SLIT tablets for JCP and HDM allergies.
  • Japanese multicenter studies assessing concomitant administration safety.
Keywords:
Japanese cedar pollinosisallergen immunotherapyallergic rhinitissubcutaneous immunotherapysublingual immunotherapy

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  • Analysis of treatment duration, adherence rates, and clinical benefits.

    • Main Results:

    • SLIT tablets reduced symptom scores by approximately 30% with a high safety profile.
    • Most adverse events were mild, local irritations; serious events were rare.
    • Concomitant administration of JCP and HDM SLIT tablets was confirmed as safe.
    • JCP SLIT demonstrated cross-efficacy for Japanese cypress pollinosis.
    • A high adherence rate of approximately 80% was observed.

    Conclusions:

    • SLIT tablets are effective and safe for managing allergic rhinitis caused by JCP and HDM in Japan.
    • The non-invasive nature and sustained efficacy of SLIT contribute to its central role in allergic rhinitis management.
    • Proper patient selection and education are crucial for optimizing SLIT adherence and outcomes.