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Renal Dysfunction Complicating the Management of Hematologic Diseases
Sai Zhou1,2, Jieni Yu1,2, Weiying Feng1,2
1Department of Hematology, Shaoxing People's Hospital, Shaoxing, People's Republic of China.
European Journal of Haematology
|June 28, 2026
Summary
Renal dysfunction is a common complication in hematologic diseases, impacting treatment options and patient outcomes. Recognizing kidney impairment as a key factor in managing these conditions is crucial for effective care.
Area of Science:
- Nephrology
- Hematology
- Oncology
Background:
- Renal dysfunction frequently complicates hematologic diseases, appearing at diagnosis or during treatment.
- Kidney impairment arises from disease biology, therapies, infections, or transplantation-related issues.
Purpose of the Study:
- To highlight the significant impact of renal dysfunction on the management of hematologic diseases.
- To emphasize considering renal impairment as a modifier of treatment strategies.
Main Methods:
- Review of clinical practice and therapeutic considerations in hematologic diseases with renal dysfunction.
- Analysis of how kidney function affects chemotherapy, targeted therapies, immunotherapy, and transplantation.
Main Results:
- Impaired kidney function affects therapeutic feasibility, dose intensity, and supportive care.
- Renal impairment influences antimicrobial selection and eligibility for hematopoietic stem cell transplantation (HSCT).
- Renal dysfunction has prognostic significance and can alter therapeutic goals.
Conclusions:
- Renal dysfunction is not an isolated comorbidity but a critical factor modifying hematologic management.
- Integrating renal status into treatment planning is essential for optimizing outcomes in patients with hematologic diseases.
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