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Insomnia Symptoms and Psychopathology in Individuals at Clinical High Risk for Psychosis
Brian J Miller1, Madelyn Granat2, William V McCall1
1Department of Psychiatry and Health Behavior, Augusta University, Augusta, Georgia, USA.
Aim:
Insomnia is common in the clinical course of schizophrenia, including in individuals at clinical high risk for psychosis (CHR-P). We previously found associations between insomnia and psychosis-risk symptoms in CHR-P. We attempted to replicate findings in an independent cohort.
Method:
We explored associations between insomnia and psychosis-risk symptoms in CHR-P individuals in the Accelerating Medicines Partnership Schizophrenia (AMP SCZ) program (n = 269). We investigated relationships between insomnia and psychosis-risk symptoms (Brief Psychiatric Rating Scale [BPRS]).
Results:
The prevalence of any terminal and initial insomnia at AMP SCZ baseline was 28% and 38%, respectively. After controlling for potential confounders, insomnia was a significant indicator of higher BPRS total (β = 0.33) and positive (β = 0.22), affect (β = 0.34), and activation (β = 0.13) subscale scores.
Discussion:
Insomnia is prevalent and associated with psychosis-risk symptoms in CHR-P individuals. Findings are clinically relevant and highlight the need for more rigorous assessment and treatment of insomnia in this population.
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