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Related Concept Videos

Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...
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Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
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Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...

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Related Experiment Video

Updated: Jun 30, 2026

Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
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Reprogramming in delipidated adipocytes: metabolism, regulation and progress.

Zhanshuo Chang1, Yunjun Liao2, Wenqing Jiang3

  • 1Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Cell Death Discovery
|June 28, 2026
PubMed
Summary
This summary is machine-generated.

Mature fat cells can transform into stem cells, offering new avenues for regenerative medicine. This process involves metabolic and epigenetic changes, challenging traditional views of cell identity.

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An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function
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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
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An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function
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An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

Published on: May 4, 2021

Area of Science:

  • Cell Biology
  • Stem Cell Research
  • Metabolic Engineering

Background:

  • Mature adipocytes, traditionally viewed as terminally differentiated cells, can undergo dedifferentiation.
  • This dedifferentiation challenges established concepts of cell fate determination and mature cell identity.
  • Dedifferentiated adipocytes represent a promising endogenous source for stem cells in humans.

Purpose of the Study:

  • To review the molecular mechanisms and metabolic remodeling involved in adipocyte dedifferentiation.
  • To explore the potential of dedifferentiated adipocytes in regenerative medicine.
  • To highlight advanced research techniques for studying adipocyte dedifferentiation.

Main Methods:

  • Review of in vitro and in vivo studies on adipocyte dedifferentiation protocols.
  • Analysis of metabolic pathways, including lipid metabolism and energy metabolite remodeling.
  • Examination of organelle remodeling, protein alterations, and epigenetic modifications.
  • Discussion of advanced techniques like lineage tracing and single-cell RNA sequencing.

Main Results:

  • Adipocyte dedifferentiation involves significant lipid droplet depletion and metabolic reprogramming.
  • Key intracellular substances, energy metabolites, proteins, and organelles undergo remodeling.
  • Epigenetic modifications play a crucial role in regulating the transition between differentiation stages.
  • Advanced techniques enable precise tracking and dynamic analysis of dedifferentiation processes.

Conclusions:

  • Mature adipocytes possess plasticity, enabling their conversion into mesenchymal stem cells.
  • Understanding adipocyte dedifferentiation provides insights into cell fate and regenerative potential.
  • Further research using advanced methods will refine our understanding and applications of dedifferentiated adipocytes.