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Integrated Endocrine-Endothelial Biomarker Alterations in Chronic Occupational Arsenic Exposure.

Murat Büyükşekerci1, Servet Birgin Iritaş2, Lütfiye Tutkun3

  • 1Ankara Atatürk Sanatorium Training and Research Hospital, Department of Pharmacology, Ankara, Türkiye.

Journal of Occupational and Environmental Medicine
|June 29, 2026
PubMed
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Chronic occupational arsenic exposure harms thyroid function and causes endothelial dysfunction. This study highlights the need for integrated biomarker surveillance in workplace health monitoring.

Area of Science:

  • Environmental Health
  • Endocrinology
  • Toxicology

Background:

  • Occupational exposure to arsenic is a significant public health concern.
  • Arsenic's impact on thyroid homeostasis and endothelial function requires further investigation.
  • An integrated biomarker approach can provide comprehensive insights into arsenic toxicity.

Purpose of the Study:

  • To assess the effects of chronic occupational arsenic exposure on thyroid hormones and endothelial dysfunction.
  • To utilize an integrated biomarker strategy for evaluating arsenic's health impacts.
  • To establish correlations between arsenic exposure levels and specific biomarkers.

Main Methods:

  • Cross-sectional study involving 85 arsenic-exposed male workers and 85 controls.
Keywords:
Arsenic exposureAsymmetric dimethylarginineBiomonitoringEndothelial dysfunctionOccupational exposureThyroid hormones

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  • Measurement of urinary arsenic levels as a biomarker of exposure.
  • Analysis of thyroid hormones (triiodothyronine, thyroxine, thyroid-stimulating hormone) and endothelial biomarkers (ADMA, SDMA).
  • Application of correlation and multivariable regression analyses.

    • Main Results:

    • Arsenic-exposed workers exhibited lower triiodothyronine and thyroxine, and higher thyroid-stimulating hormone levels (P < 0.001).
    • Significantly elevated levels of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) were observed in exposed individuals.
    • Urinary arsenic levels correlated with endocrine and endothelial biomarkers and independently predicted ADMA and SDMA (P < 0.001).

    Conclusions:

    • Chronic occupational arsenic exposure is linked to simultaneous endocrine and endothelial system alterations.
    • The findings support the use of integrated biomarker surveillance for monitoring occupational health.
    • This study underscores the importance of assessing both thyroid and endothelial health in arsenic-exposed populations.