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Updated: Jun 30, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Palladium-Catalyzed Ring-Opening Defluoroarylation of gem-Difluorinated Spiro[2.2]pentanes with Arylboronic Acids
Wen-Mei Luo1, Zhuo-Yao Huang1, Bao-Yi Liu1
1School of Pharmacy and Food Engineering, Wuyi University, Jiangmen, Guangdong 529020, P. R. China.
Abstract:
A palladium-catalyzed ring-opening defluoroarylation of gem-difluorinated spiro[2.2]pentanes with arylboronic acids has been developed. A diverse range of multisubstituted 2-fluoro-1,3-dienes was efficiently prepared in moderate to excellent yields. The resulting conjugated diene products serve as versatile synthetic precursors, facilitating downstream derivatization through Diels-Alder reactions, cross-coupling reactions, and oxidation/reduction transformations. A variety of highly useful structural motifs were constructed, thereby expanding the utility of gem-difluorinated spiro[2.2]pentanes as versatile building blocks in organic synthesis.
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