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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...

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Updated: Jun 30, 2026

In Vivo Confocal Microscopy: A Standard Operating Procedure for the Detection of Demodex Mites at the Eyelid Margin
05:21

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Published on: July 3, 2025

Demodex Infestation in Patients With Atopic Dermatitis Treated With Dupilumab: A Case-Control Study.

Pinar Dursun1, Ayse Nur Saribas Yildirim1, Ayca Yazici1

  • 1Department of Dermatology, Mersin University Faculty of Medicine, Mersin, Turkiye.

The Journal of Dermatology
|June 29, 2026
PubMed
Summary
This summary is machine-generated.

Dupilumab treats moderate-to-severe atopic dermatitis (AD), but some patients develop persistent facial symptoms. This study found Demodex mites were more common in dupilumab-treated AD patients, suggesting a link to persistent head and neck symptoms.

Keywords:
Demodexatopic dermatitisdupilumabfacial dermatoses

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Area of Science:

  • Dermatology
  • Microbiology
  • Immunology

Background:

  • Atopic dermatitis (AD) is a chronic inflammatory skin condition.
  • Dupilumab is a key therapy for moderate-to-severe AD.
  • Persistent facial erythema during dupilumab treatment requires further investigation.

Purpose of the Study:

  • To investigate the prevalence of Demodex infestation in patients with moderate-to-severe AD treated with dupilumab.
  • To compare Demodex infestation rates between dupilumab-treated AD patients and controls not on systemic immunosuppression.
  • To explore potential associations between Demodex infestation and persistent facial symptoms in dupilumab-treated AD patients.

Main Methods:

  • Retrospective case-control study.
  • Inclusion of 61 patients: 31 on dupilumab, 30 controls.
  • Assessment of Demodex density via skin surface biopsy (≥5 mites/cm² positive).

Main Results:

  • Demodex positivity was significantly higher in dupilumab-treated patients (45.2%) versus controls (6.7%).
  • Dupilumab-treated patients with Demodex infestation were older.
  • Demodex-positive patients often reported persistent facial erythema, pruritus, and ocular symptoms.

Conclusions:

  • Demodex infestation is more prevalent in AD patients receiving dupilumab therapy.
  • Findings suggest Demodex may be associated with persistent head and neck symptoms in this population.
  • Consideration of Demodex testing for AD patients with refractory facial symptoms during dupilumab treatment is warranted.