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Published on: February 7, 2019
CPA-Catalyzed Enantioselective Assembly of Chiral 1,4-Dihydropyridines with Nonadjacent 1,3-Stereocenters
Hao-Wei Peng1, Jia-Cheng Wei1, Yu-Xun Chen1
1Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
Abstract:
Herein, we report a chiral phosphoric acid (CPA)-catalyzed asymmetric Pictet-Spengler type annulation, which enables a rapid desymmetrization of prochiral dialdehydes. The 4,5-dihydropyrrolo[1,2-a]quinoxaline (DHPQ) skeleton and a nonadjacent 1,3-stereocenter are simultaneously established for a new family of potential pharmaceutically active 1,4-dihydropyridine (1,4-DHP) compounds. The developed protocol affords high diastereoselectivity (up to 20:1 dr) and good enantioselectivity (up to 99% ee). In addition, the annulation is amenable to gram-scale operation, and the resulting adducts can be readily elaborated into diverse functional groups without erosion of enantioselectivity.
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