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Successful Engraftment After Repeat Cord Blood Transplantation Using an Identical Conditioning Regimen for MPS II
Sachio Fujita, Takashi Koike, Mayuko Shibata
1Department of Pediatrics, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. shohei-y@tokai.ac.jp.
The Tokai Journal of Experimental and Clinical Medicine
|June 29, 2026
Summary
Graft failure after cord blood transplantation (CBT) can be overcome. A second CBT using the same conditioning regimen achieved durable engraftment in a mucopolysaccharidosis type II patient, suggesting this approach is viable.
Area of Science:
- Hematology
- Pediatric Hematology
- Transplantation Immunology
Background:
- Graft failure is a significant complication in cord blood transplantation (CBT), especially for nonmalignant conditions like inherited metabolic disorders.
- Strategies for retransplantation following graft failure in CBT are not well-established and remain a subject of debate.

