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Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...

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Related Experiment Video

Updated: Jun 30, 2026

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
09:44

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Published on: November 27, 2019

Atomically Modulated WSe2 Clusters with Enhanced Biocatalytic Activity for Acute Liver Injury Management.

Ke Chen1, Ziyi Peng2, Ruoli Zhao1

  • 1Tianjin Key Laboratory of Brain Science and Neural Engineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China.

ACS Applied Materials & Interfaces
|June 29, 2026
PubMed
Summary
This summary is machine-generated.

Ultrasmall M-WSe2 clusters, engineered at the atomic level, significantly boost antioxidant capacity and enzyme-like activity. These novel clusters effectively combat oxidative stress and inflammation, showing promise for treating liver injury.

Keywords:
acute liver injuryanti-inflammatory regulationantioxidantatomic-level modulationcatalytic capacity

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Last Updated: Jun 30, 2026

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Two-dimensional WSe2 possesses tunable electronic properties and catalytic activity.
  • Pure WSe2's catalytic redox performance is limited by poor charge transfer and kinetics in oxidative conditions.

Purpose of the Study:

  • To enhance the catalytic redox performance of WSe2 by constructing ultrasmall clusters.
  • To investigate the antioxidant and anti-inflammatory effects of atomic-level modulated WSe2 clusters.

Main Methods:

  • Synthesized ultrasmall (approx. 2 nm) M-WSe2 (M = Ce, Pt, Fe) clusters via atomic-level regulation.
  • Assessed antioxidant capacity, multienzyme-like activity, and free radical scavenging ability.
  • Evaluated protective effects on hepatocytes and anti-inflammatory response in macrophages.
  • Tested efficacy in an acetaminophen-induced acute liver injury mouse model.

Main Results:

  • M-WSe2 clusters showed 2.3- to 4.3-fold higher total antioxidant capacity than pure WSe2.
  • Multienzyme-like activity increased 2.2- to 44-fold, with broad-spectrum free radical scavenging.
  • Clusters protected hepatocytes from oxidative stress and inhibited macrophage inflammation.
  • In vivo, M-WSe2 significantly reduced liver injury markers (AST, ALT by ~73%, ~76%) and restored redox balance.

Conclusions:

  • Atomic-level modulation of WSe2 into ultrasmall clusters enhances catalytic antioxidant and anti-inflammatory functions.
  • M-WSe2 clusters demonstrate significant therapeutic potential for oxidative stress and inflammation-related liver injury.
  • This study offers a rational design strategy for high-performance antioxidant nanoclusters.