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Updated: Jun 30, 2026
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Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions
Published on: March 20, 2014
Ag-Catalyzed Multicomponent Reaction To Access 9-Phosphorylated Xanthenes
Xiao-Hong Wei1, Xiu-Mei Jiang1, Xu Guo1
1Key Laboratory for Utility of Environment-Friendly Composite Materials and Biomass in University of Gansu Province, College of Chemical Engineering, Northwest Minzu University, No. 1, Northwest Xincun, Lanzhou, 730030, P. R. China.
Abstract:
This study describes an efficient multicomponent reaction of 2-hydroxybenzaldehyde, secondary phosphine oxides, and β-alkynyl ketones, which affords various 9-phosphorylated xanthenes in moderate to good yields under silver catalysis. The method is highly atom- and step-economical, representing a novel synthetic strategy for the construction of multisubstituted 9-phosphorylated xanthenes. Mechanistic studies of key intermediates indicate that the process proceeds via a sequence involving phospha-aldol, alkylation, cyclization, dehydration and cyclization.
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