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A Mouse Model of Orotracheal Intubation and Ventilated Lung Ischemia Reperfusion Surgery

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Vancomycin Protects Against Lung Injury and Promotes Butyrate Metabolism.

Jianuo Chen^1,2, Shanshan Su², Xi Zhang^3,4

¹The Fifth Affiliated Hospital of Wenzhou Medical University (Lishui Central Hospital), Lishui Hospital of Zhejiang University, Lishui, China.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology

|June 29, 2026

Summary

Gut microbiota alterations, particularly reduced butyrate, worsen lung injury. Vancomycin treatment improved gut barrier function and lung inflammation by modulating butyrate metabolism.

Keywords:

gut microflora lung injury lung‐gut axis nuclear magnetic resonance

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A Mouse Model of Orotracheal Intubation and Ventilated Lung Ischemia Reperfusion Surgery

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Inducing Acute Lung Injury in Mice by Direct Intratracheal Lipopolysaccharide Instillation

Inducing Acute Lung Injury in Mice by Direct Intratracheal Lipopolysaccharide Instillation

Published on: July 6, 2019

Area of Science:

Microbiology
Pulmonology
Metabolomics

Background:

Lung injury involves continuous inflammation, damaging lung barriers and causing hypoxia.
The gut-lung axis suggests gut microbiota influences respiratory diseases, but mechanisms are unclear.
Acute lung injury (ALI) patients exhibit gut microbiota and metabolic changes.

Purpose of the Study:

To investigate the metabolic mechanisms of gut microbiota in lung injury.
To explore the therapeutic potential of modulating gut microbiota in lung injury.

Main Methods:

Generated a mouse model of lung injury using ALI patient microbiota.
Analyzed gut microbiota composition (16S rRNA) and fecal metabolomics (1H-NMR).
Administered vancomycin to lung-injured mice to assess its effects.

Main Results:

Firmicutes were a key altered microbiota species in lung-injured mice.
Butyrate, produced by Firmicutes, was a crucial metabolite in ALI patients and mice.
Vancomycin treatment alleviated intestinal barrier dysfunction and lung inflammation, increasing colonic butyrate utilization.

Conclusions:

Gut microbiota, specifically butyrate metabolism, plays a significant role in lung injury pathogenesis.
Vancomycin treatment shows therapeutic potential for lung injury by influencing gut microbiota and butyrate metabolism.
Targeting the gut-lung axis offers a novel therapeutic strategy for respiratory diseases.