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Updated: Jun 30, 2026

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Fluorinated Gamma-carboline Derivatives as Promising Neuroprotective Candidates. Structure-Activity Relationships

Maria A Lapshina1, Elena F Shevtsova1, German L Perlovich2

  • 1Department of Medical and Biological Chemistry, Preclinical Research Center, Institute of Physiologically Active Compounds (IPAC RAS), Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 1 Severny proezd, 142432, Chernogolovka, Russian Federation.

Central Nervous System Agents in Medicinal Chemistry
|June 29, 2026
PubMed
Summary

Fluorinated gamma-carboline derivatives were synthesized to inhibit FUS protein aggregation. Compound efficacy correlated with lipophilicity but inversely with hydrogen bond capacity, suggesting off-target interactions limit therapeutic potential.

Keywords:
FUS aggregationGamma-carboline derivativescytosolic aggregatesfluorinated γ‑carboline.lipophilicitypartition coefficientsproteinopathy

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