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Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

Non-Canonical Wnt Signaling Pathways

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

Non-Canonical Wnt Signaling Pathways

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

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Related Experiment Video

Updated: Jun 30, 2026

The Soft Agar Colony Formation Assay

The Soft Agar Colony Formation Assay

Published on: October 27, 2014

SEZ6L2 Promotes Cervical Carcinogenesis by Activating the Wnt Signaling Pathway.

Min Hu^1,2, Rengong Zhuo³, Yaling Tang¹

¹Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361003, People's Republic of China.

Recent Patents on Anti-Cancer Drug Discovery

|June 29, 2026

Summary

This summary is machine-generated.

Seizure-related 6 homolog-like 2 (SEZ6L2) drives cervical cancer progression by activating Wnt/β-catenin signaling and promoting epithelial-mesenchymal transition. SEZ6L2 is a potential prognostic biomarker and therapeutic target for cervical cancer.

Keywords:

Cervical cancer EMT SEZ6L2 Wnt /β-catenin biomarker carcinogenesis.

Related Experiment Videos

Last Updated: Jun 30, 2026

The Soft Agar Colony Formation Assay

The Soft Agar Colony Formation Assay

Published on: October 27, 2014

Area of Science:

Oncology
Molecular Biology
Biochemistry

Background:

Cervical cancer (CC) remains a significant global health challenge.
Understanding the molecular drivers of CC progression is crucial for developing effective therapies.

Purpose of the Study:

To investigate the biological role and molecular mechanisms of seizure-related 6 homolog-like 2 (SEZ6L2) in cervical cancer (CC).
To evaluate SEZ6L2 as a potential therapeutic target and prognostic biomarker in CC.

Main Methods:

Analysis of SEZ6L2 expression in CC tissues and cell lines.
In vitro functional assays (proliferation, migration, invasion) and in vivo tumor models.
Bioinformatic analyses (GSEA, Metascape) and miRNA prediction/validation (TargetScan, dual-luciferase assay).

Main Results:

SEZ6L2 is overexpressed in CC and associated with poor prognosis.
SEZ6L2 knockdown inhibits CC cell proliferation, migration, invasion, and tumor growth.
SEZ6L2 activates the Wnt/β-catenin pathway, promoting Epithelial-Mesenchymal Transition (EMT).
hsa-miR-1271-5p was identified as a direct upstream regulator of SEZ6L2.

Conclusions:

SEZ6L2 acts as an oncoprotein in CC by activating Wnt/β-catenin signaling and promoting EMT.
SEZ6L2 is a promising prognostic biomarker and therapeutic target for cervical cancer.
Hsa-miR-1271-5p may suppress SEZ6L2, offering potential therapeutic strategies for CC.