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Efficacy and Safety of a Novel Sodium Hyaluronate Composite Solution via Mesotherapy for Facial Rejuvenation: A
Rongya Yang1, Yi Zhang2, Hongyi Zhao2
1From the Department of Dermatology, The Seventh Medical Center of PLA General Hospital, Beijing, China.
Background:
Facial skin aging drives demand for minimally invasive rejuvenation. The technique of injecting skin boosters into the dermis through mesotherapy is increasingly used to improve signs of skin aging. This study evaluates the efficacy and safety of a novel sodium hyaluronate-based composite solution (containing sodium hyaluronate, glycine, proline, leucine, and lysine) for facial rejuvenation.
Methods:
Participants aged 18 to 65 years with facial skin concerns (dryness, dullness, enlarged pores, reduced elasticity, or fine wrinkles) were randomized in a 2:1 ratio into a treatment group or a control group. The treatment group received 3 monthly intradermal injections, whereas the control group received no intervention. The primary endpoint was the efficacy rate 1 month after the final treatment using the Global Aesthetic Improvement Scale. Secondary endpoints included efficacy rates at different time points and changes in skin hydration and elasticity. Safety was monitored throughout.
Results:
Of 456 enrolled participants, 439 completed the study (287 treatment, 152 control; 92.94% women). One month posttreatment, the treatment group showed a 97.56% efficacy rate, significantly higher than the control group's 3.95% (P < 0.001). Significant improvements in skin hydration and elasticity were observed in the treatment group (P < 0.05) and sustained for up to 3 months. The adverse event incidence was only 1.67%, and all of them were mild to moderate, with no serious events reported.
Conclusions:
The skin booster (a novel sodium hyaluronate composite solution) delivered via mesotherapy is effective for improving signs of skin aging. With a favorable safety profile, it offers a validated therapeutic option for facial rejuvenation.
