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Updated: Jun 30, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Primary Sjögren's syndrome-associated interstitial lung disease: a case report with favourable response to
Negar Naseri1, Nadia Jalili1, Farzad Rafiei1
1Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract:
Severe pulmonary involvement in primary Sjögren's syndrome presents a therapeutic challenge, particularly when conventional immunosuppression is insufficient. We report on the case of a 50-year-old woman with interstitial lung disease and profound gas exchange impairment (DLCO 17%). Despite initial treatment with azathioprine, clinical response was inadequate. Early escalation to tocilizumab was followed by marked clinical and radiological improvement. This case highlights the potential importance of timely biologic intervention in severe disease and suggests that advanced functional impairment may still be reversible. Limitations include a single-case design and concomitant therapy.
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