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Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
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Updated: Jun 30, 2026

Sequencing of Bacterial Microflora in Peripheral Blood: our Experience with HIV-infected Patients
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Published on: June 11, 2011

Calprotectin Levels in HIV-Infected Patients: Correlations With Disease Progression and Intestinal Inflammation.

Huiyun Fan1, Zhongyun Deng2, Yong Qing3

  • 1Department of Dermatology, People's Hospital of Leshan, Leshan, China, leshan-hospital.com.

AIDS Research and Treatment
|June 29, 2026
PubMed
Summary

Calprotectin, a key inflammatory marker, is elevated in HIV patients, indicating intestinal inflammation and immune dysfunction. Noninvasive serum and fecal tests can monitor disease progression and guide treatment.

Keywords:
HIV infectionS100A8/A9calprotectinintestinal mucosa

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Area of Science:

  • Immunology
  • Gastroenterology
  • Infectious Diseases

Background:

  • Persistent intestinal inflammation is a challenge in HIV patients despite antiretroviral therapy (ART).
  • Calprotectin (S100A8/A9) is a potential biomarker for inflammatory disorders, but its role in HIV-related gut inflammation requires further study.

Purpose of the Study:

  • To investigate the role of calprotectin as a biomarker for intestinal inflammation in HIV-infected individuals.
  • To correlate calprotectin levels with disease severity and immune status (CD4+ T-cell counts).

Main Methods:

  • Recruited HIV-infected patients (AIDS-stage and asymptomatic) and healthy controls.
  • Collected serum, fecal samples, and colonic biopsies for calprotectin analysis (ELISA, immunohistochemistry, Western blot).
  • Assessed intestinal inflammation via histology and correlated calprotectin levels with CD4+ T-cell counts.

Main Results:

  • Serum and fecal calprotectin levels were significantly higher in HIV-infected groups, especially in AIDS-stage patients.
  • Intestinal inflammation severity positively correlated with S100A8/A9 protein expression.
  • Calprotectin levels showed a strong inverse correlation with CD4+ T-cell counts and significant correlations across serum, feces, and mucosal tissues.

Conclusions:

  • Calprotectin is a sensitive biomarker for intestinal inflammation and immune dysfunction in HIV.
  • Noninvasive serum and fecal calprotectin assays can reliably assess disease status and guide clinical management in HIV patients.