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U.S. Psychedelic Use and Microdosing in 2025: Insights from a Probability-Based and Nationally Representative Survey.

Michelle Priest, Beau Kilmer, Ben Senator

Rand Health Quarterly

|June 29, 2026

Summary

Many US states are exploring alternatives to psychedelic prohibition. This study presents survey data on the use of 11 psychedelic substances, including microdosing prevalence for psilocybin, LSD, and MDMA.

Keywords:

Controlled Substances and Illegal Drugs Drug Markets and Supply Drug Policy and Trends Mental Health Treatment

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Area of Science:

Psycho-pharmacology
Public Health Policy

Background:

US states are increasingly considering policy changes regarding psychedelic substance prohibition for nonclinical use.
This shift necessitates data to inform public health and policy discussions.

Purpose of the Study:

To present new survey data on the usage patterns of 11 psychedelic substances.
To analyze the prevalence of microdosing for specific substances like psilocybin, LSD, and MDMA.

Main Methods:

National survey data collection on psychedelic substance use.
Analysis of self-reported usage, including frequency and dosage.
Specific focus on microdosing patterns for psilocybin, LSD, and MDMA.

Main Results:

Data on the prevalence of use for 11 different psychedelic substances.
Detailed findings on the practice of microdosing, including its application to psilocybin, LSD, and MDMA.
Insights into current nonclinical psychedelic use trends.

Conclusions:

The findings provide empirical data to inform ongoing policy debates surrounding psychedelic substances.
Understanding microdosing prevalence is crucial for future research and regulatory considerations.
This study contributes to the evidence base for nonclinical psychedelic use in the US.