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Updated: Jun 30, 2026

A Mouse Model of Intestinal Partial Obstruction
Published on: March 5, 2018
Adult intussusception caused by solitary intestinal Peutz-Jeghers polyp mimicking a malignant colon cancer
Zheng Liu1, Qin Peng2, Yongmei Wen2
1Department of General Surgery, The First Affiliated Hospital of Gannan Medical University, No. 23 Qingnian Road, Ganzhou 341699, Jiangxi, China.
Insights
Adult intussusception is rare, often caused by tumors. A Peutz-Jeghers polyp mimicked cancer in a 30-year-old man, highlighting the need for intraoperative exploration to prevent misdiagnosis.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Genetics
Background:
- Adult intussusception is a rare cause of intestinal obstruction, typically linked to neoplastic lesions.
- Peutz-Jeghers syndrome (PJS) is an inherited disorder characterized by hamartomatous polyps and increased cancer risk.
- Distinguishing benign polyps from malignant tumors in adults with intussusception can be challenging.
Abstract:
Adult intussusception is rare, accounting for ~1% of intestinal obstruction cases, and most cases are caused by neoplastic lesions. This report describes a 30-year-old male patient with a solitary Peutz-Jeghers syndrome hamartomatous polyp that mimicked colon cancer preoperatively. The patient had no mucocutaneous pigmentation, family history of polyposis or malignancy, and no STK11/LKB1 mutation. Whole-exome sequencing identified two novel heterozygous variants in POLE and EXO1. Intraoperative exploration of the terminal ileum is critical to avoid misdiagnosis and unnecessary colectomy.
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