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Updated: Jun 30, 2026

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
Published on: June 22, 2016
The Dual Roles of Regulatory B Cells in Infection, Cancer, and Immunity.
Anni Feng1, Qilong Li1, Ning Jiang1
1Key Laboratory of Livestock Infectious Diseases,Ministry of Education College of Animal Science and Veterinary Medicine, Shenyang Agricultural University Research Unit for Pathogenic Mechanisms of Zoonotic Parasites of Chinese Academy of Medical Sciences Shenyang China.
Regulatory B cells (Bregs) are crucial for immune balance, secreting IL-10 and other molecules. While they prevent autoimmunity, Bregs can also worsen infections and cancers by suppressing immune responses.
Area of Science:
- Immunology
- Cell Biology
Background:
- Regulatory B cells (Bregs) are key for immune homeostasis.
- Their function involves IL-10, IL-35, TGF-β, and PD-1/PD-L1 pathways.
Purpose of the Study:
- To review the immunoregulatory roles of Bregs in various diseases.
- To highlight the dual function of Bregs in health and disease.
Main Methods:
- Literature review of Bregs' functions.
- Analysis of Bregs' roles in infectious diseases, cancers, autoimmune disorders, and transplantation.
Main Results:
- Bregs protect against autoimmunity and aid transplant tolerance.
- Bregs can promote chronic infections and cancers by suppressing immunity.
Conclusions:
- Bregs exhibit a functional dichotomy, acting as critical immune regulators.
- Modulating Bregs offers therapeutic potential, requiring further research.
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