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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

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Trends in Increased Infection Risk Deceased Organ Donors. A Two-Centre Retrospective Study.

Oscar A Fernández-García1, Justin Co1, Tanya Suandork1

  • 1Department of Medicine, Division of Infectious Diseases, University of Alberta, Edmonton, Alberta, Canada.

Canadian Journal of Kidney Health and Disease
|June 29, 2026
PubMed
Summary
This summary is machine-generated.

The proportion of increased risk donors (IRD) for hepatitis B, C, and HIV is rising in Canada, driven by factors like drug use. Current donor risk assessments have limitations, with many unknown responses impacting data accuracy.

Keywords:
HIVdonor derived infectiondonor screeninghepatitis Bhepatitis C

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Area of Science:

  • Transplant immunology
  • Infectious disease epidemiology
  • Public health policy

Background:

  • Canadian regulations mandate labeling organ donors as increased risk (IRD) if they have risk factors for hepatitis B (HBV), hepatitis C (HCV), and HIV.
  • Assessing trends in IRD rates and associated risk factors is crucial for organ donation and transplantation safety.

Purpose of the Study:

  • To evaluate trends in the rate of increased risk organ donors (IRD) in Canada.
  • To examine specific donor risk factors over time.
  • To determine the association between donor risk factors and screening results for HBV, HCV, and HIV.

Main Methods:

  • Retrospective analysis of deceased organ donors from two Canadian transplant centers (2013-2022).
  • Trend analysis of IRD proportions and specific risk factors.
  • Exploration of associations between risk factors and serological screening outcomes.

Main Results:

  • 22.3% of donors (332/1491) were classified as IRD, with a significant upward trend in Alberta.
  • Increased donor drug use and overdose as cause of death were strongly linked to HCV infection (OR 18.03 and 6.48).
  • Men who have sex with men (MSM) were not found to have an increased risk for HBV, HCV, or HIV; however, "I don't know" responses were frequent (up to 20%).

Conclusions:

  • A rising proportion of IRD organ donations is observed in Canadian transplant centers.
  • Current regulatory criteria for IRD may not fully capture all relevant risk factors for HBV/HCV/HIV.
  • Limitations in donor risk assessment, indicated by frequent "I don't know" responses, necessitate refinement for accurate epidemiological insights.