Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antipsychotic Drugs: Typical and Atypical Agents

Antipsychotic Drugs: Typical and Atypical Agents

Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...

Drug Therapy

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications

Psychosis: Goals of Pharmacotherapy

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...

Psychosis and Antipsychotic Drugs: Overview

Psychosis and Antipsychotic Drugs: Overview

The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic symptoms in all...

Antipsychotic Drugs: Therapeutic Uses and Side Effects

Antipsychotic Drugs: Therapeutic Uses and Side Effects

Antipsychotic drugs primarily block dopamine and serotonin receptors and cholinergic, adrenergic, and histaminergic receptors, thereby reducing hallucinations and delusions in conditions like schizophrenia. However, they can trigger unwanted extrapyramidal effects such as dystonias, Parkinson-like symptoms, and tardive dyskinesia.
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...

Insulin Formulations: Types and Delivery

Insulin Formulations: Types and Delivery

Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into rapid-acting...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Impact of Clinical Characteristics of Patients with Mental Disorders on the Long-Term Effects of Electroconvulsive Therapy.

Journal of clinical medicine·2026

Same author

Financing Regimes and Case-Mix Complexity in Psychiatric Hospitals Beyond the Pandemic Shock-Insights from a Regional European Healthcare System.

Healthcare (Basel, Switzerland)·2026

Same author

Ketamine and Esketamine in Obsessive-Compulsive Disorder: A Scoping Review of Clinical and Mechanistic Evidence.

Pharmaceuticals (Basel, Switzerland)·2026

Same author

Economic implications of mental health disorders: a literature review of hospitalization costs, interventions, and outcomes.

Journal of medicine and life·2026

Same author

A review of functionality assessment scales in schizophrenia.

Frontiers in psychiatry·2026

Same author

Trends in Sudden Death Among Schizophrenia Inpatients.

Medicina (Kaunas, Lithuania)·2025

Search research articles

Related Experiment Video

Updated: Jun 30, 2026

Intracameral Injection in Rats with Low Risk of Adverse Effects

Intracameral Injection in Rats with Low Risk of Adverse Effects

Published on: May 31, 2024

Second-Generation Long-Acting Injectable Antipsychotics: A Comprehensive Assessment of Effectiveness, Safety, and

Petru Ifteni^1,2, Paula-Simina Petric^1,2, Andreea Violeta Popa^1,2

¹Faculty of Medicine, Transilvania University of Brașov, Brașov, Romania.

Neuropsychiatric Disease and Treatment

|June 29, 2026

Summary

Romanian psychiatrists prefer aripiprazole long-acting injectables (LAIs) for schizophrenia due to clinical benefits. Addressing patient trust and system barriers like availability can increase second-generation LAI use.

Keywords:

adherence efficacy long-acting injectable antipsychotics relapse safety schizophrenia

More Related Videos

Development of a Virtual Reality Assessment of Everyday Living Skills

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

Related Experiment Videos

Last Updated: Jun 30, 2026

Intracameral Injection in Rats with Low Risk of Adverse Effects

Intracameral Injection in Rats with Low Risk of Adverse Effects

Published on: May 31, 2024

Development of a Virtual Reality Assessment of Everyday Living Skills

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

Area of Science:

Psychiatry
Pharmacology
Clinical Medicine

Background:

Second-generation long-acting injectable antipsychotics (SG-LAIs) offer improved adherence and outcomes in schizophrenia but are underutilized.
Limited data exists on Romanian psychiatrists' perspectives on SG-LAIs.

Purpose of the Study:

To evaluate Romanian psychiatrists' attitudes and prescribing habits concerning SG-LAIs.
To identify key factors influencing the adoption and barriers to SG-LAI use.

Main Methods:

A cross-sectional survey was administered to psychiatrists in Romania.
Psychiatrists rated available SG-LAIs (aripiprazole, olanzapine, paliperidone, risperidone) on various clinical and practical parameters.

Main Results:

Aripiprazole LAI was rated highest for efficacy, safety, patient functioning, and overall preference.
Improved adherence and reduced relapse risk were primary drivers for LAI prescription.
Barriers included patient trust, hospital supply issues, and limited formulation availability.

Conclusions:

Romanian psychiatrists favor aripiprazole LAI, driven by clinical advantages.
Enhancing SG-LAI utilization requires addressing patient concerns and overcoming system-level obstacles such as availability and indications.