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Updated: Jun 30, 2026
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ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection
Published on: February 10, 2017
Risk factors for esophageal stricture after circumferential endoscopic submucosal dissection: a preliminary,
Yang Bai1, Wei-Xing Yang2, Min Qiao3
1Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Frontiers in Medicine
|June 29, 2026
Summary
Post-circumferential endoscopic submucosal dissection (cESD) strictures are common, but submucosal steroid pre-injection strategy (SSPS) offers better protection than combined steroid therapy (CST). Extensive circumferential involvement over 50 mm is a key risk factor for stricture development.
Area of Science:
- Gastroenterology
- Endoscopy
- Oncology
Background:
- Post-circumferential endoscopic submucosal dissection (cESD) esophageal stricture is a challenging complication.
- Combined steroid therapy (CST) has limited efficacy.
- Submucosal steroid pre-injection strategy (SSPS) is a novel prophylactic approach.
Purpose of the Study:
- To identify risk factors for post-cESD stricture.
- To evaluate the efficacy of SSPS versus CST in preventing strictures.
- To focus on steroid-based prophylaxis strategies.
Main Methods:
- Multicenter, retrospective, case-control study.
- 55 patients undergoing cESD with SSPS or CST prophylaxis.
- Logistic regression analysis to identify risk factors and compare prophylactic measures.
Main Results:
- Longitudinal length of circumferential involvement >50 mm was an independent risk factor for stricture (OR 9.10).
- SSPS significantly reduced stricture risk compared to CST (OR 0.22).
- Extensive circumferential involvement was linked to stricture with CST but not SSPS.
Conclusions:
- Longitudinal length >50 mm predicts post-cESD stricture.
- SSPS offers superior protection against esophageal stricture compared to CST.
- SSPS may mitigate stricture risk in high-risk cases, warranting further investigation.
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