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Updated: Jun 30, 2026

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model

Published on: March 5, 2022

Brain alteration of PCOS: neuroimaging and function.

Ningxiao Jiang¹, Jie Deng², Changjin Bao³

¹Department of Reproductive Medicine, Shandong Medical and Pharmaceutical University Hospital, Shandong Medical and Pharmaceutical University, Binzhou, Shandong Province, China.

Frontiers in Neurology

|June 29, 2026

Summary

Polycystic ovary syndrome (PCOS) is linked to brain abnormalities, including pituitary enlargement and reduced gray matter. These neuroimaging changes may explain cognitive and emotional issues in PCOS patients.

Keywords:

brain alteration cerebral functional endocrine diseases neuroimaging polycystic ovary syndrome

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Area of Science:

Neuroendocrinology
Neuroimaging
Women's Health

Background:

Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder with poorly understood pathogenesis.
PCOS is significantly associated with structural and functional brain abnormalities.

Purpose of the Study:

To review neuroimaging alterations and functional brain changes in PCOS patients.
To explore relationships between brain changes, endocrine-metabolic profiles, behavior, cognition, and emotion.

Main Methods:

Review of neuroimaging studies in PCOS patients.
Analysis of structural changes (pituitary, gray matter, corpus callosum) and functional activity.
Correlation with endocrine-metabolic, behavioral, cognitive, and emotional data.

Main Results:

Observed pituitary gland enlargement, reduced gray matter volume, and corpus callosum damage.
Brain alterations correlate with abnormal glucose metabolism, disordered eating, and cognitive/emotional changes.
Elevated μ-opioid receptor binding and altered orbitofrontal cortex activity noted.

Conclusions:

Neuroimaging findings suggest limbic system dysfunction underlying PCOS symptoms.
Brain alterations offer insights into PCOS pathophysiology and potential therapeutic targets.
Further research is needed to clarify mechanistic questions in PCOS neurobiology.