Predictive Value of the Lowest Serum Albumin Level During Hospitalization in Patients With Intracerebral Hemorrhage

This study aimed to explore the potential association between the lowest serum albumin concentration during hospitalization and the prognosis of patients with intracerebral hemorrhage (ICH) in order to provide a scientific basis for selecting and optimizing clinical treatment options.

A total of 268 patients with ICH were retrospectively analyzed. The study outcome was 90-day mRS (mRS > 2). Univariate and multivariate analyses and ROC curve analyses were used to identify the correlation between the lowest serum albumin concentration and the prognosis of patients with ICH.

(1) The lowest serum albumin concentration, Glasgow Coma Score (GCS), and hematoma volume were independent predictors of outcome in patients with ICH (p < 0.05). (2) A good outcome in patients with ICH was predicted when the lowest serum albumin levels were > 31.8 g/L (AUC = 0.849, 95% CI: 0.801-0.890, p < 0.001), the GCS was > 11 (AUC = 0.878, 95% CI: 0.833-0.915, p < 0.001), and the hematoma volume was ≤ 23.6 mL (AUC = 0.863, 95% CI: 0.815 to 0.902, p < 0.001). (3) The lowest serum albumin concentration was statistically different between GCS (3-8, 9-12, 13-15: 29.30 [3.90], 33.80 [6.85], 36.70 [5.55]) (χ ² = 69.696, p < 0.001) and had a positive correlation with GCS (r _s  = 0.569).

The lowest serum albumin concentration during hospitalization was an independent predictor of poor outcome in ICH, and when serum albumin was greater than 31.8 g/L, it predicted a good outcome. In addition, the degree of consciousness disturbance may have some influence on the serum albumin level, and the specific mechanism needs further study.