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Updated: Jun 30, 2026

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Published on: October 2, 2019
Preserved Medial Temporal Lobe Flexibility Predicts Memory Generalization Only in the Context of Good Sleep Quality
Payton White1, Miray Budak1, Soodeh Moallemian1
1Center for Molecular & Behavioral Neuroscience, Rutgers University-Newark, 197 University Ave., Suite 209, Newark, NJ 07102 USA.
Objectives:
Poor sleep quality is a risk factor for Alzheimer's disease (AD). Older African Americans experience disproportionately high rates of sleep disturbance and AD. Medial temporal lobe (MTL) flexibility reflects dynamic neural reorganization and may be a marker of generalization performance. This study examined whether sleep quality moderates the association between MTL flexibility and memory generalization.
Methods:
Fifty older African Americans (MeanAge=69.7±6.21 years; 80% women) underwent rs-fMRI to quantify MTL flexibility, Rutgers Acquired Equivalence Task for memory generalization, and Pittsburgh Sleep Quality Index for sleep quality.
Results:
Greater MTL flexibility was associated with better generalization (r=0.367, p=.017). Good sleepers showed higher MTL flexibility (F(1,44)=8.11, ηp2=.156, p=.007) and superior generalization (F(1,46)= 12.33, ηp2=.211, p=.001). Sleep quality significantly moderated the MTL flexibility-generalization relationship (β=-1.519, p=.012).
Conclusions:
Preserved MTL flexibility may confer generalization only in good sleepers, suggesting that sleep disturbance may disrupt the MTL neural resilience among older African Americans.
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