A five-domain functional framework for integrative physiology: a coherent and operational approach to whole-body...

Area of Science:

• Integrative Physiology
• Systems Biology
• Functional Anatomy

Background:

• Traditional physiological models use a six-layered structural hierarchy (molecules to organism).
• This layered approach has limitations for understanding functions spanning multiple levels, like homeostasis and thermoregulation.
• Integrative physiology lacks a coherent framework for multi-level functional interactions.

Purpose of the Study:

• Introduce a novel 5-domain functional framework based on extracellular fluid (ECF) and intracellular fluid (ICF) compartment interactions.
• Develop a Blueprint for Quantitative Functional Organization (BQFO) to systematically organize quantitative physiological functions.
• Provide a more realistic epistemology and methodology for understanding bodily functions.

Main Methods:

• Logical analysis of ECF-ICF relationships to derive five functional domains.
• Development of the Blueprint for Quantitative Functional Organization (BQFO) platform.
• Application of the framework and platform to organize known physiological functions and mathematical relationships.

Main Results:

• A 5-domain functional framework organizing processes by operational logic, not anatomical position.
• The Blueprint for Quantitative Functional Organization (BQFO) creates a hierarchical organization for quantitative physiological functions.
• Demonstration of a unified and flexible visualization of multi-level physiological coordination.

Conclusions:

• The 5-domain framework and BQFO offer practical tools for integrating complex physiological functions.
• These developments provide a more realistic epistemology and methodology for studying the body.
• The proposed framework and platform can advance integrative physiology, interdisciplinary research, and education.