Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Micelles01:30

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
Colloids03:22

Colloids

Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Desmearing Bonse-Hart USANS data using Bayesian Gaussian process regression.

The Journal of chemical physics·2026
Same author

Programmable Electrostatics in Charge-Patterned Polypeptoid Micelles Probed by Small-Angle Neutron Scattering.

Macromolecules·2026
Same author

Corona Chain-Controlled Transition from Ostwald Ripening-Grown Hexagonal Platelets to Screw-Dislocation Spirals in Liquid-Crystalline Polypeptoids.

Nano letters·2026
Same author

An algebraic convolution formulation for multiple-scattering correction in small-angle neutron scattering.

The Journal of chemical physics·2026
Same author

Microstructure Control of Polymer Films via Air-Assisted Electrospray for Binderless Electrodes.

ACS applied polymer materials·2026
Same author

A Bayesian desmearing algorithm for Bonse-Hart USANS with anisotropic scattering.

The Journal of chemical physics·2026

Related Experiment Video

Updated: Jun 30, 2026

Assembly and Characterization of Polyelectrolyte Complex Micelles
08:44

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

Customizing Ionic Micelles by Dynamic Coassembly of Sequence-Defined Peptoid Block Copolymers.

Erin Tsai1, Meng Zhang1, Guan-Rong Huang2,3

  • 1Department of Chemistry and Macromolecular Studies Group, Louisiana State University, Baton Rouge, Louisiana 70803, United States.

Macromolecules
|June 29, 2026
PubMed
Summary

Mixing sequence-defined peptoid block copolymers (BCPs) with varying charge patterns allows tunable micellar assembly. This approach enables control over size, geometry, and interfacial hydrophobicity for diverse applications.

More Related Videos

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
10:53

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
11:42

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers

Published on: June 20, 2019

Related Experiment Videos

Last Updated: Jun 30, 2026

Assembly and Characterization of Polyelectrolyte Complex Micelles
08:44

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
10:53

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
11:42

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers

Published on: June 20, 2019

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Supramolecular Chemistry

Background:

  • Sequence-defined polymers offer precise control over conformation and interactions.
  • Mixing polymers is a strategy to create novel mesoscale assemblies.
  • Thermodynamic favorability is key for successful polymer mixing over self-sorting.

Purpose of the Study:

  • Investigate the aqueous assembly of binary mixtures of sequence-defined peptoid block copolymers (BCPs).
  • Explore how varying charge patterns and stoichiometry influence micellar aggregate formation.
  • Determine the tunability of micellar size, geometry, and interfacial hydrophobicity.

Main Methods:

  • Förster Resonance Energy Transfer (FRET) experiments to observe dynamic coassembly.
  • Small-angle X-ray scattering (SAXS) to analyze micellar size and aggregation.
  • Binding studies with 8-anilino-1-naphthalenesulfonic acid (ANS) to assess interfacial hydrophobicity.

Main Results:

  • Peptoid chains with varying charge patterns dynamically coassemble into hybrid micellar aggregates.
  • Micellar size and aggregation number are controllable via stoichiometry.
  • Interfacial hydrophobicity of micelles is tailorable by adjusting the molar ratio of distinct sequences.

Conclusions:

  • Mixing sequence-defined peptoid chains with varying charge patterns effectively produces tunable micellar assemblies.
  • This strategy expands the chemical design space for materials discovery.
  • Potential applications include enhanced drug encapsulation and solubilization.