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Related Experiment Video

Updated: Jun 30, 2026

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

Optical Coherence Tomography Features of Retinal Leukemic Infiltrates and Their Association With Visual Prognosis.

Dhwanee Agarwal¹, Mudit Tyagi², Rajeev Reddy Pappuru²

¹Anant Bajaj Retina Institute, GMR Varalakshmi campus, L V Prasad Eye Institute, Visakhapatnam, AP, India.

Journal of Vitreoretinal Diseases

|June 29, 2026

Summary

Optical coherence tomography (OCT) reveals that cystoid macular edema and ellipsoid zone loss are key indicators of poor vision in patients with leukemic retinopathy. These OCT biomarkers predict visual outcomes regardless of leukemia type or infiltrate characteristics.

Keywords:

cystoid macular edema ellipsoid zone loss leukemic retinopathy optical coherence tomography retinal infiltrates

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Last Updated: Jun 30, 2026

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats

Published on: January 10, 2019

Area of Science:

Ophthalmology
Hematology
Medical Imaging

Background:

Leukemic retinopathy involves leukemic cell infiltration in the retina, potentially affecting vision.
Optical coherence tomography (OCT) is a valuable imaging technique for visualizing retinal structures.

Purpose of the Study:

To characterize the OCT features of retinal leukemic infiltrates.
To assess the association between OCT findings and visual/systemic prognosis in leukemic retinopathy.

Main Methods:

Retrospective, cross-sectional multicenter study of leukemia patients with OCT imaging.
Analysis of demographic, clinical, and OCT data.
Univariate and multivariate regression to identify OCT biomarkers for visual outcomes.

Main Results:

Seventy-seven eyes from 47 patients were analyzed; 39% showed leukemic infiltrates, primarily in inner retinal layers.
Cystoid macular edema (CME) and ellipsoid zone (EZ) loss were significant predictors of poor vision on both univariate and multivariate analyses.
Infiltrate location, size, and configuration did not correlate with visual prognosis.

Conclusions:

Retinal leukemic infiltrates typically affect inner retinal layers.
OCT-identified cystoid macular edema and ellipsoid zone disruption are crucial biomarkers for predicting poor visual prognosis in leukemic retinopathy.