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Updated: Jun 30, 2026
Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
Published on: July 17, 2012
Comparative accuracy of spectral computed tomography and conventional computed tomography in colorectal cancer
Dan Wei1,2, Jing-Yi Zhang2, Ping-Tai Tang1
1Department of Radiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, China.
Background:
Accurate pre-treatment staging is essential for risk stratification and treatment planning in colorectal cancer (CRC). Spectral computed tomography (CT) provides energy-resolved reconstructions that may improve local and nodal assessment compared with conventional contrast-enhanced CT.
Methods:
This retrospective study included 340 adults with pathologically confirmed CRC who underwent spectral CT (n = 151) or conventional CT (n = 189) before definitive treatment between September 2023 and September 2025. The reference standard was postoperative histopathologic staging for resected cases or a composite standard incorporating biopsy, imaging, and clinical follow-up for non-surgical cases. Primary outcomes were overall TNM accuracy and component T, N, and M staging accuracy. Agreement was assessed using kappa statistics. Binary diagnostic performance was calculated for nodal metastasis and distant metastasis. Multivariable logistic regression was performed to account for potential residual confounding.
Results:
Spectral CT showed higher overall TNM accuracy than conventional CT (74.2% vs 63.0%, P = 0.028). It also demonstrated superior T-stage accuracy (74.2% vs 57.7%, P = 0.002) and N-stage accuracy (74.8% vs 64.0%, P = 0.032), whereas M-stage accuracy was similar (90.7% vs 91.0%, P = 0.930). Agreement with the reference standard was higher for spectral CT for overall TNM (weighted κ = 0.815 vs 0.795), T stage (0.759 vs 0.663), and N stage (0.599 vs 0.430). For M1 detection, spectral CT showed higher sensitivity (83.8% vs 72.2%) with slightly lower specificity (93.0% vs 95.4%). In adjusted analyses, spectral CT remained independently associated with correct overall TNM staging (adjusted odds ratio 1.91, 95% confidence interval 1.14-3.19, P = 0.014).
Conclusions:
Under standardized protocols, spectral CT demonstrated higher overall TNM staging accuracy than conventional CT, primarily through improved T and N classification, while M staging performance was comparable.
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