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MASLD and sarcopenia research (2012-2025): a multi-database bibliometric analysis.

Keyan Gao1, Liwen Xun1, Shalei Hao1

  • 1Department of Endocrinology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.

Frontiers in Nutrition
|June 29, 2026
PubMed
Summary

Research on metabolic dysfunction-associated steatotic liver disease (MASLD) and sarcopenia shows a growing focus on early fibrosis risk and lifestyle interventions. Understanding the liver-muscle axis is key for personalized nutrition strategies.

Keywords:
bibliometricsliver–muscle axismetabolic dysfunction–associated steatotic liver diseaseprecision nutritionsarcopenia

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Area of Science:

  • Metabolic Health
  • Gerontology
  • Nutritional Science

Background:

  • Metabolic dysfunction-associated steatotic liver disease (MASLD) and sarcopenia share common mechanisms like insulin resistance and inflammation.
  • Their co-occurrence increases risks for hepatic fibrosis, cardiovascular events, and mortality.
  • Investigating the liver-muscle axis is crucial for developing precision nutrition.

Purpose of the Study:

  • To map research trends and nutrition implications within the liver-muscle axis.
  • To identify emerging themes and temporal evolution of research in MASLD and sarcopenia.
  • To provide evidence for precision nutrition strategies.

Main Methods:

  • Bibliometric analysis of 701 publications (2012-2025) from Web of Science and Scopus.
  • Utilized R package bibliometrix, CiteSpace, and VOSviewer for network and keyword analysis.
  • Applied BERTopic modeling for theme identification and reviewed PubMed cohort studies.

Main Results:

  • Research field grew 36.6% annually, with China, South Korea, and the US as core collaborators.
  • Research focus shifted from mechanisms to clinical phenotyping, risk prediction, and interventions.
  • Emerging themes include sarcopenia-fibrosis risk, lipid metabolism, and cardiometabolic management.
  • Low muscle mass/function linked to higher MASLD risk/progression (HR 1.18-7.96).

Conclusions:

  • Research is shifting towards early fibrosis prediction, lifestyle interventions, and metabolic management.
  • Further investigation of the liver-muscle axis is essential.
  • Standardized muscle assessment is needed to support precision nutrition.