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MASLD and sarcopenia research (2012-2025): a multi-database bibliometric analysis.
Keyan Gao1, Liwen Xun1, Shalei Hao1
1Department of Endocrinology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Frontiers in Nutrition
|June 29, 2026
Summary
Research on metabolic dysfunction-associated steatotic liver disease (MASLD) and sarcopenia shows a growing focus on early fibrosis risk and lifestyle interventions. Understanding the liver-muscle axis is key for personalized nutrition strategies.
Area of Science:
- Metabolic Health
- Gerontology
- Nutritional Science
Background:
- Metabolic dysfunction-associated steatotic liver disease (MASLD) and sarcopenia share common mechanisms like insulin resistance and inflammation.
- Their co-occurrence increases risks for hepatic fibrosis, cardiovascular events, and mortality.
- Investigating the liver-muscle axis is crucial for developing precision nutrition.
Purpose of the Study:
- To map research trends and nutrition implications within the liver-muscle axis.
- To identify emerging themes and temporal evolution of research in MASLD and sarcopenia.
- To provide evidence for precision nutrition strategies.
Main Methods:
- Bibliometric analysis of 701 publications (2012-2025) from Web of Science and Scopus.
- Utilized R package bibliometrix, CiteSpace, and VOSviewer for network and keyword analysis.
- Applied BERTopic modeling for theme identification and reviewed PubMed cohort studies.
Main Results:
- Research field grew 36.6% annually, with China, South Korea, and the US as core collaborators.
- Research focus shifted from mechanisms to clinical phenotyping, risk prediction, and interventions.
- Emerging themes include sarcopenia-fibrosis risk, lipid metabolism, and cardiometabolic management.
- Low muscle mass/function linked to higher MASLD risk/progression (HR 1.18-7.96).
Conclusions:
- Research is shifting towards early fibrosis prediction, lifestyle interventions, and metabolic management.
- Further investigation of the liver-muscle axis is essential.
- Standardized muscle assessment is needed to support precision nutrition.
