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Related Experiment Video

Updated: Jun 30, 2026

Bioinspired Soft Robot with Incorporated Microelectrodes
08:24

Bioinspired Soft Robot with Incorporated Microelectrodes

Published on: February 28, 2020

Engineering bioinspired pH-responsive hydrogels for smart wound repair.

Rubia Khan1, Usama Ahmad1, Indranil Kumar Yadav2

  • 1Faculty of Pharmacy, Integral University, Kursi Road, Lucknow-226026, India. usamaahmad.10@outlook.com.

Nanoscale
|June 29, 2026
PubMed
Summary

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Intelligent pH-responsive hydrogels offer advanced wound healing solutions but face translational hurdles. This review critically analyzes engineering principles and design considerations to guide the development of next-generation regenerative wound dressings.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Regenerative Medicine

Background:

  • Chronic and infected wounds pose significant clinical challenges unmet by conventional dressings.
  • pH-responsive hydrogels show promise as intelligent biomaterials for dynamic wound microenvironment interaction.
  • Significant translational barriers hinder the clinical and commercial progression of laboratory hydrogel prototypes.

Purpose of the Study:

  • To critically evaluate engineering principles and quantitative design considerations for smart hydrogel performance in wound healing.
  • To systematically classify pH trigger mechanisms and analyze their impact on hydrogel behavior.
  • To bridge the gap between polymer synthesis and clinical application for advanced wound dressings.

Main Methods:

Related Experiment Videos

Last Updated: Jun 30, 2026

Bioinspired Soft Robot with Incorporated Microelectrodes
08:24

Bioinspired Soft Robot with Incorporated Microelectrodes

Published on: February 28, 2020

  • Systematic classification of pH trigger mechanisms in hydrogels.
  • Model-based analysis of relationships between crosslinking density, mesh size, swelling, and release kinetics.
  • Evaluation of practical constraints including sterilization, fabrication, and regulatory pathways.

    • Main Results:

    • Detailed analysis of fundamental engineering principles governing pH-responsive hydrogel performance.
    • Identification of key design considerations for optimizing swelling, release kinetics, and multifunctional synergies.
    • Highlighting practical limitations in sterilization, scale-up, and regulatory approval processes.

    Conclusions:

    • A design-oriented framework and standardized metrics are proposed to advance hydrogel development.
    • Addressing engineering and practical constraints is crucial for translating smart hydrogels into clinical reality.
    • This review provides a roadmap for developing next-generation regenerative wound dressings.