Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Area of Science:

• Pharmacology
• Natural Products Chemistry
• Cardiovascular Medicine

Background:

• Natural products (NPs) possess diverse biological activities, attracting interest for therapeutic applications.
• Cardiovascular disease (CVD) management is an ongoing challenge, with thrombosis being a key pathological process.
• Complementary therapies for CVD, particularly those targeting thrombotic events, are actively sought.

Purpose of the Study:

• To review the role of bioactive natural products in preventing and managing cardiovascular disease (CVD).
• To assess the potential of natural products as complementary therapeutic agents for thrombotic processes in CVD.
• To explore nutritional epigenetics, artificial intelligence, and interactions with anticoagulant drugs in this context.

Main Methods:

• Literature review focusing on bioactive compounds from natural sources with antithrombotic properties.
• Analysis of processing, extraction, and isolation methodologies for active constituents.
• Examination of evidence on chronic dietary intake, pharmacokinetics, and drug interactions.
• Exploration of nutritional epigenetics and the role of artificial intelligence in natural product discovery.

Main Results:

• Bioactive natural products exhibit significant antiplatelet and antithrombotic activities, relevant to CVD management.
• Natural food sources contain compounds with well-documented antithrombotic effects.
• Interactions between chronic dietary intake of bioactive compounds and anticoagulant therapies warrant further investigation.
• Nutritional epigenetics and AI present novel avenues for personalized CVD prevention and drug discovery.

Conclusions:

• Bioactive natural products hold substantial potential as complementary agents in CVD management, primarily via antithrombotic mechanisms.
• Understanding gene-diet interactions and leveraging AI can enhance personalized CVD treatment strategies.
• Further research into the pharmacokinetic and pharmacodynamic interactions of natural products with conventional anticoagulants is crucial.