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Related Concept Videos

The Extracellular Matrix01:29

The Extracellular Matrix

Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
The Extracellular Matrix01:42

The Extracellular Matrix

In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.Composition of the Extracellular MatrixThe extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse molecules.
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult body.
A...
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...

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Updated: Jun 30, 2026

All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System
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All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System

Published on: December 20, 2021

Mechanobiology-Driven Metabolic Reprogramming: Integrative Roles of YAP/TAZ Signaling and Extracellular Matrix

Arul Narayanasamy1, Panimalar Abirami Karuppusamy1, Roselin Gnanarajan1

  • 1Disease Proteomics Laboratory, Department of Zoology, Bharathiar University, Coimbatore, Tamil Nadu, India.

Cell Biology International
|June 29, 2026
PubMed
Summary
This summary is machine-generated.

Mechanobiology links physical forces to cellular metabolism regulation across organ systems. Understanding mechanometabolic pathways, particularly YAP/TAZ signaling, is key for treating diseases like cardiovascular and metabolic disorders.

Keywords:
Hippo pathwayYAP/TAZ signalingbiomaterialsmechanometabolismtissue stiffness

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Area of Science:

  • Mechanobiology
  • Cellular Metabolism
  • Systems Biology

Background:

  • Mechanobiology integrates physical forces with cellular processes, impacting metabolism and epigenetics.
  • Extracellular matrix (ECM) dynamics and mechanotransduction pathways' roles in metabolic reprogramming are not fully understood.
  • A focused mechanometabolic framework is needed to integrate cardiovascular, skeletal, and endocrine systems.

Purpose of the Study:

  • To present a mechanometabolic framework integrating cardiovascular, skeletal, and endocrine systems.
  • To elucidate the role of YAP/TAZ signaling axis in mechanotransduction and metabolic regulation.
  • To examine the contribution of aberrant mechanotransduction to disease progression and therapeutic potential.

Main Methods:

  • Literature review of mechanobiology, mechanotransduction, and metabolic reprogramming.
  • Integration of ECM remodeling, cytoskeletal tension, and force-dependent signaling pathways.
  • Analysis of YAP/TAZ signaling axis and its downstream metabolic targets.

Main Results:

  • YAP/TAZ signaling acts as a mechanosensitive regulator of glycolysis, mitochondrial function, and biosynthesis.
  • Aberrant mechanotransduction contributes to cardiovascular remodeling, fibrosis, and metabolic diseases.
  • The gut-bone axis represents a bidirectional mechanochemical network influencing bone and systemic metabolism.

Conclusions:

  • Mechanobiology is a critical regulator of metabolic reprogramming across multiple organ systems.
  • Targeting mechanometabolic pathways offers therapeutic potential for human diseases.
  • Further research is needed to address limitations in model systems and translational barriers.