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Related Concept Videos

Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...

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Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
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Reply to "Methodological Challenges in Interpreting SAA-Defined Imaging Subgroups in Parkinson's Disease"

Shannon Y Chiu1, Wei-En Wang2, Robin Chen2

  • 1Department of Neurology, Mayo Clinic College of Medicine, Scottsdale, Arizona, USA.

Annals of Neurology
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No abstract available in PubMed .

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