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Updated: Jun 30, 2026

Establishment and Genetic Manipulation of Murine Hepatocyte Organoids

Establishment and Genetic Manipulation of Murine Hepatocyte Organoids

Published on: February 12, 2022

Biobanked Liver Organoids: A Roadmap for Precision Hepatology.

Elisa J Cabré¹, Silvia Cobo-González¹, Luis Sánchez Valle¹

¹Facultad De Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, España.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology

|June 29, 2026

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Cryopreservation allows archived human tissues to generate renewable organoids for disease modeling. Standardizing these biobanks is crucial for advancing precision hepatology research.

Area of Science:

Hepatology
Regenerative Medicine
Biobanking

Background:

Cryopreservation enables the use of archived human tissues for generating organoids, offering renewable experimental models.
This approach expands access to patient-specific materials, reduces variability, and facilitates longitudinal studies.

Purpose of the Study:

To highlight the potential of cryopreservation-enabled organoid biobanking for precision hepatology.
To propose a roadmap for the coordinated implementation of these biobanks.

Main Methods:

Review of existing proof-of-concept studies on deriving liver organoids from cryopreserved human tissues.
Analysis of current challenges including lack of standardized protocols and data infrastructures.

Main Results:

Keywords:

FAIR data, governance Liver organoids biobanking cryopreservation precision hepatology translational research

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Last Updated: Jun 30, 2026

Establishment and Genetic Manipulation of Murine Hepatocyte Organoids

Establishment and Genetic Manipulation of Murine Hepatocyte Organoids

Published on: February 12, 2022

Development and Optimization of A Human Hepatocellular Carcinoma Patient-Derived Organoid Model for Potential Target Identification and Drug Discovery

Development and Optimization of A Human Hepatocellular Carcinoma Patient-Derived Organoid Model for Potential Target Identification and Drug Discovery

Published on: August 18, 2023

Human Liver Spheroids from Peripheral Blood for Liver Disease Studies

Human Liver Spheroids from Peripheral Blood for Liver Disease Studies

Published on: January 27, 2023

Liver organoids can be successfully derived from cryopreserved human tissues, maintaining viability and disease-relevant phenotypes.
The success is sensitive to source material, culture lines, and protocol specifics.

Conclusions:

Cryopreservation-enabled organoid biobanking is essential infrastructure for precision hepatology.
Standardization of protocols, quality benchmarks, and data integration is needed for widespread adoption.