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Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

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Migraine and auditory dysfunction: beyond comorbidity.

Wandi Xu¹, Ni Zhai^2,3, Jingyu Chen¹

¹Department of Otorhinolaryngology, Head and Neck Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Journal of Neurology

|June 29, 2026

Summary

Migraine is linked to hearing loss, tinnitus, and hyperacusis due to systemic sensory sensitization. Understanding these auditory symptoms in migraine patients is crucial for better diagnosis and treatment.

Keywords:

Central sensitization Hearing loss Hyperacusis Migraine Neurogenic inflammation Tinnitus

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Last Updated: Jun 30, 2026

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

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Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R

Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R

Published on: December 9, 2022

Area of Science:

Neurology
Otolaryngology
Systemic Disorders

Background:

Migraine is a systemic disorder involving multisensory sensitization.
Auditory symptoms like hearing loss, tinnitus, and hyperacusis are common in migraine patients.
Nearly two-thirds of migraine patients show auditory electrophysiological abnormalities.

Purpose of the Study:

To synthesize epidemiological, audiological, and pathophysiological data linking migraine to auditory dysfunction.
To explore the underlying mechanisms of migraine-associated auditory symptoms.
To categorize current and emerging therapeutic strategies for these conditions.

Main Methods:

Review of epidemiological, audiological, and pathophysiological data.
Analysis of the peripheral-to-central continuum of pathology.
Categorization of therapeutic strategies based on clinical objectives.

Main Results:

Migraine-associated auditory dysfunction involves microvascular ischemia, aberrant fluid exchange, neurochemical imbalances, and central sensitization.
Pathological axes include anatomical/hydrodynamic vulnerabilities, neurochemical disruptions, and central neural network plasticity.
Therapeutic strategies target upstream migraine pathways, cochlear protection, and central hypersensitivity.

Conclusions:

Migraine significantly impacts auditory function through complex pathophysiological mechanisms.
A framework for therapeutic strategies is proposed, addressing migraine's systemic and central effects.
Further research is needed for early identification, precise phenotyping, and cross-disciplinary management.